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Literature summary for 2.7.4.14 extracted from

  • Seagrave, J.; Reyes, P.
    Pyrimidine nucleoside monophosphate kinase from rat bone marrow cells: a kinetic analysis of the reaction mechanism (1987), Arch. Biochem. Biophys., 254, 518-525.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
Rattus norvegicus
UDP product inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.067
-
ATP pH 7.1, 37°C Rattus norvegicus
0.13
-
CMP pH 7.1, 37°C Rattus norvegicus
0.35
-
ATP pH 7.1, 37°C Rattus norvegicus
1.4
-
UMP pH 7.1, 37°C Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + UMP = ADP + UDP reaction mechanism is sequential and nonequilibrium in nature, substrates bind to the enzyme in a random order, substrate binding is cooperative Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
Rattus norvegicus
-