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Literature summary for 2.7.4.14 extracted from

  • Maness, P.; Orengo, A.
    A pyrimidine nucleoside monophosphate kinase from rat liver (1975), Biochemistry, 14, 1484-1489.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol activates Rattus norvegicus
dithiothreitol activates Rattus norvegicus
glutathione activates Rattus norvegicus
L-Cys activates Rattus norvegicus
reduced DL-alpha-lipoic acid activates Rattus norvegicus
thioredoxin activity is strictly dependent upon sulfhydryl reducing agents. Reduced thioredoxin is by far the most effective Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
CMP above 0.13 mM, substrate inhibition Rattus norvegicus
additional information no substrate inhibition with 3 mM dCMP and 1 mM UMP Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.027
-
dCMP
-
Rattus norvegicus
0.03
-
CMP
-
Rattus norvegicus
0.04
-
UMP
-
Rattus norvegicus
0.053
-
UMP
-
Rattus norvegicus
0.98
-
CMP
-
Rattus norvegicus
2.77
-
dCMP
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for phosphorylation of CMP, UMP and dCMP by either ATP or dCTP Rattus norvegicus
Mn2+ with CMP as phosphate donor, Mn2+, Ni2+ and Ca2+ are able to substitute for Mg2+, 100%, Mn2+, 42%, Ni2+, 15% and Ca2+, 13% Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
30.17
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + CMP
-
Rattus norvegicus ADP + CDP
-
?
ATP + dCMP
-
Rattus norvegicus ADP + dCDP
-
?
ATP + UMP
-
Rattus norvegicus ADP + UDP
-
?
CTP + CMP
-
Rattus norvegicus CDP + CDP
-
?
dATP + CMP
-
Rattus norvegicus dADP + CDP
-
?
dATP + dCMP
-
Rattus norvegicus dADP + dCDP
-
?
dATP + UMP
-
Rattus norvegicus dADP + ADP
-
?
dCTP + CMP
-
Rattus norvegicus dCDP + CDP
-
?
dGTP + CMP
-
Rattus norvegicus dGDP + CDP
-
?
dTTP + CMP
-
Rattus norvegicus dTDP + CDP
-
?
dUTP + CMP
-
Rattus norvegicus dUDP + CDP
-
?
GTP + CMP
-
Rattus norvegicus GDP + CDP
-
?
ITP + CMP
-
Rattus norvegicus IDP + CDP
-
?
ITP + UMP
-
Rattus norvegicus IDP + UDP
-
?
UTP + CMP
-
Rattus norvegicus UDP + CDP
-
?
XTP + CMP
-
Rattus norvegicus XDP + CDP
-
?