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Literature summary for 2.7.4.14 extracted from

  • Maness, P.; Orengo, A.
    Activation of rat liver pyrimidine nucleoside monophosphate kinase (1976), Biochim. Biophys. Acta, 429, 182-190.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol at 5 mM: reduction in molecular weight from approximately 53000 Da to 17000 Da. This low molecular weight form is partially active in the presence of 2-mercaptoethanol. In absence of 2-mercaptoethanol the low molecular weight form is inactive. At 50 mM: full reactivation of the CMP(ATP) kinase activity followed by dCMP(ATP) and CMP(dCTP) Rattus norvegicus
thioredoxin activates Rattus norvegicus

General Stability

General Stability Organism
the enzyme is unstable when fully activated, anions promoting hydrophobic interactions stabilize the active conformation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-