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Literature summary for 2.7.3.2 extracted from
- Isoenzyme-specific thermostability of human cytosolic creatine kinase (2010), Int. J. Biol. Macromol., 47, 27-32.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.3 | - |
ATP | hybrid form consisting of muscle and brain creatine kinase isoforms, pH and temperature not specified in the publication | Homo sapiens |  |
| 0.35 | - |
ATP | wild-type hBBCK, pH and temperature not specified in the publication | Homo sapiens | |
| 0.44 | - |
ATP | wild-type hMMCK, pH and temperature not specified in the publication | Homo sapiens | |
| 3.9 | - |
Creatine | wild-type hBBCK, pH and temperature not specified in the publication | Homo sapiens | |
| 5 | - |
Creatine | hybrid form consisting of muscle and brain creatine kinase isoforms, pH and temperature not specified in the publication | Homo sapiens | |
| 6.2 | - |
Creatine | wild-type hMMCK, pH and temperature not specified in the publication | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 85300 | - |
wild-type hMMCK | Homo sapiens |
| 86200 | - |
wild-type hMMCK | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| muscle | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + creatine | - |
Homo sapiens | ADP + phosphocreatine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| brain creatine kinase | - |
Homo sapiens |
| hBBCK | - |
Homo sapiens |
| hMMCK | - |
Homo sapiens |
| muscle creatine kinase | - |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 42.2 | - |
T0.5: 42.2°C wild-type hBBCK | Homo sapiens |
| 48 | - |
wild-type hBBCK gets completely inactivated above 48°C | Homo sapiens |
| 52 | - |
T0.5: 52°C hybrid form consisting of muscle and brain creatine kinase isoforms | Homo sapiens |
| 57.2 | - |
T0.5: 57.2°C wild-type hMMCK | Homo sapiens |
| 62 | - |
wild-type hMMCK gets completely inactivated above 62°C | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 138 | - |
Creatine | co-substrate: ATP, wild-type hMMCK, pH and temperature not specified in the publication | Homo sapiens | |
| 238 | - |
Creatine | co-substrate: ATP, hybrid form consisting of muscle and brain creatine kinase isoforms, pH and temperature not specified in the publication | Homo sapiens | |
| 417 | - |
Creatine | co-substrate: ATP, wild-type hBBCK, pH and temperature not specified in the publication | Homo sapiens | |
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