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Literature summary for 2.7.3.2 extracted from

  • Lenz, H.; Schmidt, M.; Welge, V.; Kueper, T.; Schlattner, U.; Wallimann, T.; Elsaesser, H.P.; Wittern, K.P.; Wenck, H.; Staeb, F.; Blatt, T.
    Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology (2007), Mol. Cell. Biochem., 306, 153-162.
    View publication on PubMed
Search for more literature for 2.7.3.2

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
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cytosol HaCaT cells express low levels of cytoplasmic creatine kinase (BB-CK) and high levels of mitochondrial creatine kinase (uMiCK). HeLa-S3 cells express high levels of cytoplasmic creatine kinase (BB-CK) and low levels of mitochondrial creatine kinase (uMiCK) Homo sapiens 5829
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mitochondrion mitochondrial isoform plays the most crucial role in maintaining cell viability by stabilizing contact sites between inner and outer mitochondrial membranse and maintaining local metabolic channeling Homo sapiens 5739
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mitochondrion HaCaT cells express low levels of cytoplasmic creatine kinase (BB-CK) and high levels of mitochondrial creatine kinase (uMiCK). HeLa-S3 cells express high levels of cytoplasmic creatine kinase (BB-CK) and low levels of mitochondrial creatine kinase (uMiCK). The mitochondrial CK isoform plays the most crucial role in maintaining cell viability by stabilizing contact sites between inner and outer mitochondrial membranes and maintaining local metabolite channeling, thus avoiding transition pore opening which eventually results in activation of caspase cell-death pathways Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Homo sapiens P06732
-
-
Homo sapiens P12277
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell expresses low levels of cytoplasmic, high levels of mitochondrial creatine kinase. Targeting the dominating isoform by its siRNA has strong effect on overall enzyme activity. Inhibition of mitochondrial isoform causes a strong decline in cell viability and cell proliferation and also substantial alteration of mitochondrial morphology as well as mitochondrial membrane topology Homo sapiens
-
HaCaT cell HaCaT cells express low levels of cytoplasmic creatine kinase (BB-CK) and high levels of mitochondrial creatine kinase (uMiCK). HeLa-S3 cells express high levels of cytoplasmic creatine kinase (BB-CK) and low levels of mitochondrial creatine kinase (uMiCK) Homo sapiens
-
HeLa-S3 cell expresses high levels of cytoplasmic, low levels of mitochondrial creatine kinase. Targeting the dominating isoform by its siRNA has strong effect on overall enzyme activity. Inhibition of mitochondrial isoform causes a strong decline in cell viability and cell proliferation and also substantial alteration of mitochondrial morphology as well as mitochondrial membrane topology Homo sapiens
-
HeLa-S3 cell HaCaT cells express low levels of cytoplasmic creatine kinase (BB-CK) and high levels of mitochondrial creatine kinase (uMiCK). HeLa-S3 cells express high levels of cytoplasmic creatine kinase (BB-CK) and low levels of mitochondrial creatine kinase (uMiCK) Homo sapiens
-

Synonyms

Synonyms Comment Organism
BB-CK
-
 Homo sapiens
uMiCK
-
 Homo sapiens