Crystallization (Comment) | Organism |
---|---|
NMR screening of inhibitors docked to the crystal structure of enzyme. A phenylfuroic acid may enter into a pocket adjacent to the nucleotide binding site | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(4-([(benzoylphenyl)amino]carbonyl)phenyl)-2-furoic acid | 35% inhibition, docking energy -49.5 kcal/mol | Oryctolagus cuniculus | |
5-(4-([(biphenyl-4-ylmethyl)amino]carbony)phenyl)-2-furoic acid | 63% inhibition, docking energy -51.8 kcal/mol | Oryctolagus cuniculus | |
5-(4-benzoylbiphenyl-4-yl)-2-furoic acid | 63% inhibition, docking energy -46.3 kcal/mol | Oryctolagus cuniculus | |
5-(4-[(benzylamino)carbonyl]phenyl)-2-furoic acid | 20% inhibition, docking energy -47.4 kcal/mol | Oryctolagus cuniculus | |
5-(4-[[(benzoylphenyl)amino]carbonyl]phenyl)-2-furoic acid | - |
Oryctolagus cuniculus | |
5-(4-[[(biphenyl-4-ylmethyl)amino]carbony]phenyl)-2-furoic acid | - |
Oryctolagus cuniculus | |
5-[4-[(benzylamino)carbonyl]phenyl]-2-furoic acid | - |
Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + creatine | - |
Oryctolagus cuniculus | ADP + phosphocreatine | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.025 | - |
5-(4-([(benzoylphenyl)amino]carbonyl)phenyl)-2-furoic acid | - |
Oryctolagus cuniculus | |
0.025 | - |
5-(4-[[(benzoylphenyl)amino]carbonyl]phenyl)-2-furoic acid | - |
Oryctolagus cuniculus |