Literature summary for 2.7.3.2 extracted from

Zanette, F.; Victor, E.G.; Scaini, G.; Di-Pietro, P.B.; Cardoso, D.C.; Cristiano, M.P.; Dal-Pizzol, F.; Paula, M.M.; Streck, E.L.
Modulation of creatine kinase activity by ruthenium complexes (2007), J. Inorg. Biochem., 101, 267-273.

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Activating Compound

Activating Compound	Comment	Organism	Structure
trans-[RuCl2(3,4-pyridinedicarboxylic acid)4]	administration at 180.7 micromol/kg, increase of creatine kinase activity in hippocampus, striatum, cerebral cortex and heart, but not in skeletal muscle. No effect on enzyme in vitro	Rattus norvegicus
trans-[RuCl2(3,5-pyridinedicarboxylic acid)4]	administration at 180.7 micromol/kg, increase of creatine kinase activity in hippocampus, striatum, cerebral cortex and heart, but not in skeletal muscle. No effect on enzyme in vitro	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	no effect: trans-[RuCl2(4-pyridinecarboxylic acid)4]	Rattus norvegicus
trans-[RuCl2(3-pyridinecarboxylic acid)4]	administration at 180.7 micromol/kg, inhibition of creatine kinase activity in hippocampus, striatum, cerebral cortex, heart and skeletal muscle. No effect on enzyme in vitro	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
heart	-	Rattus norvegicus	-
skeletal muscle	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)