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Literature summary for 2.7.3.2 extracted from

  • Zhao, T.J.; Feng, S.; Wang, Y.L.; Liu, Y.; Luo, X.C.; Zhou, H.M.; Yan, Y.B.
    Impact of intra-subunit domain-domain interactions on creatine kinase activity and stability (2006), FEBS Lett., 580, 3835-3840.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
A76G mutation in the intra-subunit domain-domain interface, similar to wild-type in kinetics and thermal inactivation Oryctolagus cuniculus
C74A mutation in the intra-subunit domain-domain interface, no significant effect on activity and structure, decrease in stability and reactivation Oryctolagus cuniculus
C74L mutation in the intra-subunit domain-domain interface, no significant effect on activity and structure, decrease in stability and reactivation Oryctolagus cuniculus
C74M mutation in the intra-subunit domain-domain interface, no significant effect on activity and structure, decrease in stability and reactivation Oryctolagus cuniculus
C74S mutation in the intra-subunit domain-domain interface, no significant effect on activity and structure, decrease in stability and reactivation Oryctolagus cuniculus
G73A mutation in the intra-subunit domain-domain interface, decrease in activity and stability Oryctolagus cuniculus
V72A mutation in the intra-subunit domain-domain interface, decrease in activity and stability Oryctolagus cuniculus
V75A mutation in the intra-subunit domain-domain interface, no significant effect on activity and structure, decrease in stability and reactivation Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.43
-
ATP mutant C74A, 25°C Oryctolagus cuniculus
0.45
-
ATP wild-type, 25°C Oryctolagus cuniculus
0.46
-
ATP mutant A76G, 25°C Oryctolagus cuniculus
0.47
-
ATP mutant C74S, 25°C Oryctolagus cuniculus
0.51
-
ATP mutant V72A, 25°C Oryctolagus cuniculus
0.57
-
ATP mutant V75A, 25°C Oryctolagus cuniculus
0.66
-
ATP mutant C74M, 25°C Oryctolagus cuniculus
0.68
-
ATP mutant G73A, 25°C Oryctolagus cuniculus
0.7
-
ATP mutant C74L, 25°C Oryctolagus cuniculus
8.7
-
Creatine mutant C74A, 25°C Oryctolagus cuniculus
8.9
-
Creatine mutant A76G, 25°C Oryctolagus cuniculus
9
-
Creatine mutant C74S, 25°C Oryctolagus cuniculus
9.1
-
Creatine wild-type, 25°C Oryctolagus cuniculus
13.8
-
Creatine mutant V75A, 25°C Oryctolagus cuniculus
18.3
-
Creatine mutant C74M, 25°C Oryctolagus cuniculus
18.6
-
Creatine mutant C74L, 25°C Oryctolagus cuniculus
21.4
-
Creatine mutant V72A, 25°C Oryctolagus cuniculus
25
-
Creatine mutant G73A, 25°C Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus P00563
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
148
-
mutant V72A, 25°C Oryctolagus cuniculus
256
-
mutant C74M, 25°C Oryctolagus cuniculus
258
-
mutant C74L, 25°C Oryctolagus cuniculus
261
-
wild-type, 25°C Oryctolagus cuniculus
263
-
mutant V75A, 25°C Oryctolagus cuniculus
266
-
mutant C74S, 25°C Oryctolagus cuniculus
272
-
mutant A76G, 25°C Oryctolagus cuniculus
278
-
mutant C74A, 25°C Oryctolagus cuniculus
8208
-
mutant G73A, 25°C Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + creatine
-
Oryctolagus cuniculus ADP + phosphocreatine
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
mutant G73A, inactivation Oryctolagus cuniculus
48
-
wild-type, stable up to 48°C, mutant V75A, inactivation Oryctolagus cuniculus
58
-
wild-type, inactivation Oryctolagus cuniculus