Literature summary for 2.7.3.2 extracted from

Wang, P.F.; Flynn, A.J.; Naor, M.M.; Jensen, J.H.; Cui, G.; Merz, K.M.; Kenyon, G.L.; McLeish, M.J.
Exploring the role of the active site cysteine in human muscle creatine kinase (2006), Biochemistry, 45, 11464-11472.

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Protein Variants

Protein Variants	Comment	Organism
C283S/S285C	pKa value of active site cysteine increase by 1 pH unit	Homo sapiens
P284A	pKa value of active site cysteine increase by 1.2 pH units	Homo sapiens
S285A	pKa value of active site cysteine increase by 1 pH unit	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P12532	computational approach to study the contribution of side chain residues to the very low pKa value of active site cysteine	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
muscle	-	Homo sapiens	-

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Release 2023.1 (January 2023)