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Literature summary for 2.7.3.2 extracted from
- Regulation of skeletal muscle creatine kinase from a hibernating mammal (2007), Arch. Biochem. Biophys., 467, 10-19.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.68 | - |
ATP | 25°C, euthermic squirrel | Urocitellus richardsonii |  |
| 0.79 | - |
ATP | 25°C, myosin bound enzyme | Urocitellus richardsonii | |
| 1.18 | - |
ATP | 25°C, hibernating squirrel | Urocitellus richardsonii | |
| 1.2 | - |
Creatine | 25°C, myosin bound enzyme | Urocitellus richardsonii | |
| 1.62 | - |
Creatine | 25°C, euthermic squirrel | Urocitellus richardsonii | |
| 2.06 | - |
Creatine | 25°C, hibernating squirrel | Urocitellus richardsonii | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
x * 43000, SDS-PAGE | Urocitellus richardsonii |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Urocitellus richardsonii | - |
creatine kinase activity and protein are 20% lower during hibernation than in euthermia, whereas enzyme mRNA is reduced by 70%. Hibernator creatine kinase shows reduced affinity for ATP and creatine. Soluble enzyme from euthermic squirrels is a mix of phosphorylated and dephosphorylated forms. in hibernating animals only phospho-enzyme is detected | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | soluble creatine kinase from euthermic squirrels is a mix of phosphorylated and dephosphorylated forms. In hibernating animals only phospho-enzyme is detected. High and low phosphate enzyme forms show different affinities for ATP and creatine substrates, but do not differ in stability to urea denaturation | Urocitellus richardsonii |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| muscle | - |
Urocitellus richardsonii | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + creatine | - |
Urocitellus richardsonii | ADP + creatine phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 43000, SDS-PAGE | Urocitellus richardsonii |
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Release 2023.1 (January 2023)
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