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Literature summary for 2.7.13.3 extracted from
- Three (and more) component regulatory systems - auxiliary regulators of bacterial histidine kinases (2010), Mol. Microbiol., 75, 547-566.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| DivK | acts as a stimulator of both PleC and DivJ kinase activity | Caulobacter vibrioides | |
| FixT | stimulates FixL-mediated dephosphorylation of FixJ | Sinorhizobium meliloti | |
| LprF | direct regulator of KdpD | Escherichia coli | |
| LprJ | direct regulator of KdpD | Escherichia coli | |
| UhpC | UhpC stimulates UhpB autophosphorylation in the presence of D-glucose 6-phosphate | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| FixT | - |
Caulobacter vibrioides | |
| FixT | - |
Sinorhizobium meliloti | |
| KipA | - |
Bacillus subtilis | |
| Sda | - |
Bacillus subtilis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | integral membrane protein | Vibrio harveyi | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Bordetella pertussis | - |
- |
- |
| Caulobacter vibrioides | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Sinorhizobium meliloti | - |
- |
- |
| Vibrio harveyi | P54302 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Sinorhizobium meliloti |
| phosphoprotein | - |
Bacillus subtilis |
| phosphoprotein | - |
Escherichia coli |
| phosphoprotein | - |
Caulobacter vibrioides |
| phosphoprotein | - |
Bordetella pertussis |
| phosphoprotein | - |
Vibrio harveyi |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + BctC | - |
Bordetella pertussis | ? | - |
? |  |
| ATP + DivK | DivJ is the main kinase of DivK | Caulobacter vibrioides | ? | - |
? | |
| ATP + FixJ | - |
Sinorhizobium meliloti | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BctE | - |
Bordetella pertussis |
| CpxA | - |
Escherichia coli |
| DivJ | - |
Caulobacter vibrioides |
| EvgS | - |
Escherichia coli |
| FixL | - |
Sinorhizobium meliloti |
| KdpD | - |
Escherichia coli |
| KINA | - |
Bacillus subtilis |
| LuxQ | - |
Vibrio harveyi |
| PleC | - |
Caulobacter vibrioides |
| sensor histidine kinase | - |
Bacillus subtilis |
| TorS | - |
Escherichia coli |
| UhpB | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Bacillus subtilis | |
| ATP | - |
Bordetella pertussis | |
| ATP | - |
Vibrio harveyi | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Vibrio harveyi | regulated by the small molecule autoinducer AI-2 | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | FixL utilizes a heme bound to an N-terminal PAS domain to detect the amount of oxygen present in the cytoplasm through direct binding | Sinorhizobium meliloti |
| physiological function | KdpD regulates the expression of potassium transporters in response to osmolarity | Escherichia coli |
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