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Literature summary for 2.7.12.2 extracted from

  • Uchida, Y.; Osaki, T.; Yamasaki, T.; Shimomura, T.; Hata, S.; Horikawa, K.; Shibata, S.; Todo, T.; Hirayama, J.; Nishina, H.
    Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock (2012), J. Biol. Chem., 287, 8318-8326.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.2

Protein Variants

Protein Variants Comment Organism
additional information exogenous expression in cultured mammalian cells of an MKK7-JNK fusion protein, that functions as a constitutively active form of JNK, induces phosphorylation of PER2, an essential circadian component Homo sapiens
additional information exogenous expression in cultured mammalian cells of an MKK7-JNK fusion protein, that functions as a constitutively active form of JNK, induces phosphorylation of PER2, an essential circadian component Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-
nucleus
-
 Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + c-Jun N-terminal kinase Homo sapiens JNK activation ADP + phosphorylated c-Jun N-terminal kinase
-
 ?
ATP + c-Jun N-terminal kinase Mus musculus JNK activation ADP + phosphorylated c-Jun N-terminal kinase
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14733
-
-
Mus musculus Q8CE90
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast
-
 Mus musculus
-
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + c-Jun N-terminal kinase JNK activation Homo sapiens ADP + phosphorylated c-Jun N-terminal kinase
-
 ?
ATP + c-Jun N-terminal kinase JNK activation Mus musculus ADP + phosphorylated c-Jun N-terminal kinase
-
 ?

Synonyms

Synonyms Comment Organism
MKK7
-
 Homo sapiens
MKK7
-
 Mus musculus
stress kinase mitogen-activated protein kinase kinase 7
-
 Homo sapiens
stress kinase mitogen-activated protein kinase kinase 7
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction genetic inactivation of MKK7 results in an extended period of oscillation in circadian gene expression in mouse embryonic fibroblasts, genetic inactivation of the Mkk7 gene alters circadian gene expression Mus musculus
malfunction genetic inactivation of the Mkk7 gene alters circadian gene expression Homo sapiens
physiological function the stress kinase mitogen-activated protein kinase kinase 7 (MKK7) is a specific activator of c-Jun N-terminal kinase (JNK), which controls various physiological processes, such as cell proliferation, apoptosis, differentiation, and migration. Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock, overview. JNK interacts with PER2 at both the exogenous and endogenous levels, and MKK7-mediated JNK activation increases the half-life of PER2 protein by inhibiting its ubiquitination. The PER2 protein stabilization induced by MKK7-JNK fusion protein reduces the degradation of PER2 induced by casein kinase 1epsilon. MKK7 controls circadian gene expression in cultured cells Homo sapiens
physiological function the stress kinase mitogen-activated protein kinase kinase 7 (MKK7) is a specific activator of c-Jun N-terminal kinase (JNK), which controls various physiological processes, such as cell proliferation, apoptosis, differentiation, and migration. Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock, overview. JNK interacts with PER2 at both the exogenous and endogenous levels, and MKK7-mediated JNK activation increases the half-life of PER2 protein by inhibiting its ubiquitination. The PER2 protein stabilization induced by MKK7-JNK fusion protein reduces the degradation of PER2 induced by casein kinase 1epsilon. MKK7 controls circadian gene expression in cultured cells Mus musculus