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Literature summary for 2.7.12.2 extracted from

  • Qiu, J.L.; Zhou, L.; Yun, B.W.; Nielsen, H.B.; Fiil, B.K.; Petersen, K.; Mackinlay, J.; Loake, G.J.; Mundy, J.; Morris, P.C.
    Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1 (2008), Plant Physiol., 148, 212-222.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
genes mkk1 and mkk2 Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information mkk1 single mutant appears similar to the wild-type, basal levels of MPK4 activity are not impaired in them, and MKK1 is in part functionally redundant in unchallenged plants, overview, the mkk1/2 double mutant is severely dwarfed, phenotypes of mkk1/2 are due to loss-of-function of both MKK1 and MKK2, overview. Hormone levels and growth phenotypes of mkk1/2/sid2 and mkk1/2/ein2 triple mutants, overview Arabidopsis thaliana
additional information mkk2 single mutant appears similar to the wild-type, basal levels of MPK4 activity are not impaired in them, and MKK2 is in part functionally redundant in unchallenged plants, overview, the mkk1/2 double mutant is severely dwarfed, phenotypes of mkk1/2 are due to loss-of-function of both MKK1 and MKK2, overview. Hormone levels and growth phenotypes of mkk1/2/sid2 and mkk1/2/ein2 triple mutants, overview Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana Arabidopsis thaliana mitogen-activated protein kinase kinase MKK1 is implicated in biotic and abiotic stress responses as part of a signaling cascade including MEKK1 and MPK4, MKK1 and MKK2 function upstream of MPK4, overview. The mkk1/2 double mutant is similar to the mpk4 mutant, as both: (1) are dark green dwarves with curled leaves, (2) constitutively overproduce salicylic acid and exhibit enhanced resistance to biotrophic pathogens and insensitivity to JA, and (3) have enhanced basal expression of PR1 and other SA-dependent defense genes ?
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 ?
additional information Arabidopsis thaliana Arabidopsis thaliana mitogen-activated protein kinase kinase MKK2 is implicated in biotic and abiotic stress responses as part of a signaling cascade including MEKK1 and MPK4, MKK1 and MKK2 function upstream of MPK4, overview. mkk2 single mutants appear morphologically normal, the mkk1/2 double mutant is similar to the mpk4 mutant, as both: (1) are dark green dwarves with curled leaves, (2) constitutively overproduce salicylic acid and exhibit enhanced resistance to biotrophic pathogens and insensitivity to JA, and (3) have enhanced basal expression of PR1 and other SA-dependent defense genes ?
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 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q94A06 MKK1; gene mkk1
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Arabidopsis thaliana Q9S7U9 MKK2; gene mkk2
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Arabidopsis thaliana mitogen-activated protein kinase kinase MKK1 is implicated in biotic and abiotic stress responses as part of a signaling cascade including MEKK1 and MPK4, MKK1 and MKK2 function upstream of MPK4, overview. The mkk1/2 double mutant is similar to the mpk4 mutant, as both: (1) are dark green dwarves with curled leaves, (2) constitutively overproduce salicylic acid and exhibit enhanced resistance to biotrophic pathogens and insensitivity to JA, and (3) have enhanced basal expression of PR1 and other SA-dependent defense genes Arabidopsis thaliana ?
-
 ?
additional information Arabidopsis thaliana mitogen-activated protein kinase kinase MKK2 is implicated in biotic and abiotic stress responses as part of a signaling cascade including MEKK1 and MPK4, MKK1 and MKK2 function upstream of MPK4, overview. mkk2 single mutants appear morphologically normal, the mkk1/2 double mutant is similar to the mpk4 mutant, as both: (1) are dark green dwarves with curled leaves, (2) constitutively overproduce salicylic acid and exhibit enhanced resistance to biotrophic pathogens and insensitivity to JA, and (3) have enhanced basal expression of PR1 and other SA-dependent defense genes Arabidopsis thaliana ?
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 ?

Synonyms

Synonyms Comment Organism
MKK1
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 Arabidopsis thaliana
MKK2
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 Arabidopsis thaliana