Literature summary for 2.7.12.2 extracted from

Hansen, T.E.; Puntervoll, P.; Seternes, O.M.; J?rgensen, J.B.
Atlantic salmon possess three mitogen activated protein kinase kinase 6 paralogs responding differently to stress (2008), FEBS J., 275, 4887-4902.

Search for more literature for 2.7.12.2

Cloned(Commentary)

Cloned (Comment)	Organism
MKK6, DNA and amino acid sequence determination and analysis, expression analysis and phylogenetic tree, recombinant ectopical expression of c-Myc-tagged MKK6a, b, and c in CHSE-214 cells	Salmo salar

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Salmo salar

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + p38	Salmo salar	signal cascade upstream activation by phosphorylation, sorbitol induced activation of p38 in salmon TO cells does not require MKK6a, b or c	ADP + phospho-p38	-	?

Organism

Organism	UniProt	Comment	Textmining
Salmo salar	A9UK00	MKK6a; the fish does not possess a MKK3 gene	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + p38	activation by phosphorylation	Salmo salar	ADP + phospho-p38	-	?
ATP + p38	signal cascade upstream activation by phosphorylation, sorbitol induced activation of p38 in salmon TO cells does not require MKK6a, b or c	Salmo salar	ADP + phospho-p38	-	?

Synonyms

Synonyms	Comment	Organism
mitogen activated protein kinase kinase 6	-	Salmo salar
MKK6	-	Salmo salar

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Salmo salar

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Release 2023.1 (January 2023)