Literature summary for 2.7.12.2 extracted from

Lee, S.D.; Chang, S.H.; Kuo, W.H.; Ying, T.H.; Kuo, W.W.; Li, P.C.; Hsu, H.H.; Lu, M.C.; Ting, H.; Huang, C.Y.
Role of mitogen-activated protein kinase kinase in Porphyromonas gingivalis-induced myocardial cell hypertrophy and apoptosis (2006), Eur. J. Oral Sci., 114, 154-159.

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Application

Application	Comment	Organism
medicine	Porphyromonas gingivalis-secreted factors may initiate MEK/ERK signal pathways and lead to myocardial cell hypertrophy and apoptosis	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
U0126	potent MEK-1/2 inhibitor, cellular size, DNA fragmentation, nuclear condensation, and the phosphorylated ERK-1 protein products of H9c2 cells treated with Porphyromonas gingivalis medium, are all significantly reduced after pre-administration of U0126	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
H9c2 cell	components of Porphyromonas gingivalis spent culture medium not only result in increased total MEK-1 and ERK-1 protein products, but also cause increased cellular size, DNA fragmentation, and nuclear condensation	Rattus norvegicus	-
myocardium	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
MEK-1	-	Rattus norvegicus
MEK-2	-	Rattus norvegicus
mitogen-activated protein kinase kinase	-	Rattus norvegicus

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Release 2023.1 (January 2023)