Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.12.2 extracted from

  • Tan, X.; Tamori, Y.; Egami, H.; Ishikawa, S.; Kurizaki, T.; Takai, E.; Hirota, M.; Ogawa, M.
    Analysis of invasion-metastasis mechanism in pancreatic cancer: involvement of tight junction transmembrane protein occludin and MEK/ERK signal transduction pathway in cancer cell dissociation (2004), Oncol. Rep., 11, 993-998.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information dissociation factor DF induces MEK1/2 and ERK1/2 expression Mesocricetus auratus

Inhibitors

Inhibitors Comment Organism Structure
additional information occludin acts as antagonist of the MEK and ERK signaling pathway inducing cell aggregation of pancreatic cancer cells Mesocricetus auratus
U0126 MEK inhibitor Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mesocricetus auratus the enzyme is involved in the mitogen-activated protein kinase signaling pathway regulating cell dissociation of cancer cells, MEK2 is an invasion-metastasis related factor between highly and weakly invasive cells, occludin acts as antagonist ?
-
?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adenocarcinoma cell pancreatic ductal Mesocricetus auratus
-
additional information cancer cell growth patterns, overview Mesocricetus auratus
-
pancreas
-
Mesocricetus auratus
-
pancreatic cancer cell
-
Mesocricetus auratus
-
PC-1.0 cell subcutaneous tumor cell line, highly invasive Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in the mitogen-activated protein kinase signaling pathway regulating cell dissociation of cancer cells, MEK2 is an invasion-metastasis related factor between highly and weakly invasive cells, occludin acts as antagonist Mesocricetus auratus ?
-
?

Synonyms

Synonyms Comment Organism
ERK1
-
Mesocricetus auratus
ERK2
-
Mesocricetus auratus
extracellular-signal-regulated kinase
-
Mesocricetus auratus
MEK1
-
Mesocricetus auratus
MEK2
-
Mesocricetus auratus
mitogen-activated protein kinase kinase 2
-
Mesocricetus auratus