Literature summary for 2.7.12.2 extracted from

Ellinger-Ziegelbauer, H.; Brown, K.; Kelly, K.; Siebenlist, U.
Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative (1997), J. Biol. Chem., 272, 2668-2674.

Search for more literature for 2.7.12.2

Cloned(Commentary)

Cloned (Comment)	Organism
isolation of cDNA	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + protein	Homo sapiens	MEKK3 regulates the SAPK and the ERK pathway directly	ADP + phosphoprotein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q99759	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + protein	MEKK3 regulates the SAPK and the ERK pathway directly	Homo sapiens	ADP + phosphoprotein	-	?
additional information	MEKK3 activates SEK and MEK, the known kinases targeting SAPK and ERK respectively	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
MEKK3	-	Homo sapiens
mitogen-activated protein kinase kinase kinase 3	-	Homo sapiens
mitogen-activated protein kinase/ERK kinase kinase 3	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)