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Literature summary for 2.7.12.2 extracted from

  • Su, G.H.; Hilgers, W.; Shekher, M.C.; Tang, D.J.; Yeo, C.J.; Hruban, R.H.; Kern, S.E.
    Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene (1998), Cancer Res., 58, 2339-2342.
    View publication on PubMed
Search for more literature for 2.7.12.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein Homo sapiens MKK4 may participate in a tumor suppressive signaling pathway distinct from DPC4, p16, p53, and BRCA2. The enzyme is a component of a stress and cytokine-induced signal transduction pathway involving MAPK proteins, additional role for MKK4 in tumor suppression ADP + phosphoprotein
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Organism

Organism UniProt Comment Textmining
Homo sapiens P45985
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Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell line
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 Homo sapiens
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colonic cancer cell line colorectal cancer cell line Homo sapiens
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lung cancer cell line
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 Homo sapiens
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pancreatic cancer cell line
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 Homo sapiens
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testicular cancer cell line human pancreatic, lung, breast, testicle, and colorectal cancer cell lines Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein MKK4 may participate in a tumor suppressive signaling pathway distinct from DPC4, p16, p53, and BRCA2. The enzyme is a component of a stress and cytokine-induced signal transduction pathway involving MAPK proteins, additional role for MKK4 in tumor suppression Homo sapiens ADP + phosphoprotein
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 ?

Synonyms

Synonyms Comment Organism
dual specificity mitogen-activated protein kinase kinase 4
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 Homo sapiens
MKK4
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 Homo sapiens