Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? | |
ATP + adaptor protein SH2 domain-containing leukocyte protein | Homo sapiens | phosphorylation of SLP-65 on several tyrosines | ADP + phospho-[adaptor protein SH2 domain-containing leukocyte protein] | - |
? | |
ATP + immunglobulin-alpha | Homo sapiens | the inhibitory residue of Ig-alpha S197 is phosphorylated in activated B cells by Syk | ADP + phospho-[immunglobulin-alpha] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P43405 | cf. EC 2.7.10.2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
ATP + a protein | enzyme Syk phosphoryles serine and tyrosine residues | Homo sapiens | ADP + a phosphoprotein | - |
? | |
ATP + adaptor protein SH2 domain-containing leukocyte protein | - |
Homo sapiens | ADP + phospho-[adaptor protein SH2 domain-containing leukocyte protein] | - |
? | |
ATP + adaptor protein SH2 domain-containing leukocyte protein | phosphorylation of SLP-65 on several tyrosines | Homo sapiens | ADP + phospho-[adaptor protein SH2 domain-containing leukocyte protein] | - |
? | |
ATP + immunglobulin-alpha | the inhibitory residue of Ig-alpha S197 is phosphorylated in activated B cells by Syk | Homo sapiens | ADP + phospho-[immunglobulin-alpha] | - |
? | |
ATP + immunglobulin-alpha | phosphorylation of tyrosines of Ig-alpha and Ig-beta and on Ser197, immunohistochemic determination of phosphorylation site Ser197 | Homo sapiens | ADP + phospho-[immunglobulin-alpha] | - |
? | |
additional information | autophosphorylation of Syk at Tyr630 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Spleen tyrosine kinase | - |
Homo sapiens |
Syk | cf. EC 2.7.10.2 | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | rebuilding of the BCR receptor complex in S2 Drodophila melanogster system and phosphorylation and analysis with Syk overview | Homo sapiens |
physiological function | Syk is a dual-specificity kinase, phosphorylating serine and tyrosine residues, that self-regulates the signal output from the B-cell antigen receptor. The B-cell antigen receptor (BCR) comprises the membrane-bound Ig molecule and the Ig-alpha/Ig-beta heterodimer, which function as the ligand-binding and signaling subunits, respectively. The cytoplasmic tails of Ig-alpha and Ig-beta contain an immunoreceptor tyrosine-based activation motif. The ITAM tyrosines of Ig-alpha and Ig-beta are phosphorylated by Syk. And enzyme Syk (spleen tyrosine kinase) phosphorylates S197 on Ig-alpha, not only activating but also inhibiting signaling from the B-cell antigen receptor. Phosphorylation of S197 in the Ig-alpha cytoplasmic tail plays a negative role in B-cell antigen receptor (BCR) activation | Homo sapiens |