Application | Comment | Organism |
---|---|---|
diagnostics | enzyme DYRK2 expression is an independent prognostic factor and can be used as a prognostic biomarker of human colorectal cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
quantitative real-time PCR expression analysis of DYRK2 expression in colorectal carcinoma samples | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92630 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal carcinoma cell | DYRK2 level is lower in primary or metastatic colorectal carcinoma compared to adjacent normal colon tissue or non-metastatic colorectal carcinoma, respectively. DYRK2 expression analysis of in 181 archived colorectal carcinoma samples, overview | Homo sapiens | - |
esophageal adenocarcinoma cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
lung adenocarcinoma cell | - |
Homo sapiens | - |
non-small cell lung cancer cell | - |
Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
dual specificity tyrosine phosphorylation regulated kinase 2 | - |
Homo sapiens |
DYRK2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | enzyme DYRK2 is a member of the dual specificity kinase family, which can phosphorylate both Ser/Thr and Tyr substrates. At least seven DYRK family members have been identified (DYRK1A, DYRK1B, DYRK1C, DYRK2, DYRK3, DYRK4A and DYRK4B) | Homo sapiens |
physiological function | role of DYRK2 in human cancer and as a potential oncogene. Overexpression of DYRK2 predicts a better survival in human non-small cell lung cancer, low expression level of DYRK2 correlates with poor prognosis in colorectal cancer. DYRK2 expression is significantly downregulated in colorectal cancer tissues compared with adjacent non-tumorous tissues. Enzyme DYRK2 inhibits cell invasion and migration in both HCT-116 and SW-480 cells and functions as a tumor suppressor in colorectal cancer cells. DYRK2 behaves as a proapoptotic kinase through phosphorylation of p53 at S46 which promotes its apoptotic activity. Downregulation of DYRK2 also induces a G2/M arrest. DYRK2 inhibits the proliferation, cell migration and invasion of colorectal cancer cells in vitro | Homo sapiens |