Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.12.1 extracted from

  • Yan, H.; Hu, K.; Wu, W.; Li, Y.; Tian, H.; Chu, Z.; Koeffler, H.P.; Yin, D.
    Low expression of DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) correlates with poor prognosis in colorectal cancer (2016), PLoS ONE, 11, e0159954.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
diagnostics enzyme DYRK2 expression is an independent prognostic factor and can be used as a prognostic biomarker of human colorectal cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
quantitative real-time PCR expression analysis of DYRK2 expression in colorectal carcinoma samples Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92630
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal carcinoma cell DYRK2 level is lower in primary or metastatic colorectal carcinoma compared to adjacent normal colon tissue or non-metastatic colorectal carcinoma, respectively. DYRK2 expression analysis of in 181 archived colorectal carcinoma samples, overview Homo sapiens
-
esophageal adenocarcinoma cell
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
lung adenocarcinoma cell
-
Homo sapiens
-
non-small cell lung cancer cell
-
Homo sapiens
-
SW-480 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
dual specificity tyrosine phosphorylation regulated kinase 2
-
Homo sapiens
DYRK2
-
Homo sapiens

General Information

General Information Comment Organism
evolution enzyme DYRK2 is a member of the dual specificity kinase family, which can phosphorylate both Ser/Thr and Tyr substrates. At least seven DYRK family members have been identified (DYRK1A, DYRK1B, DYRK1C, DYRK2, DYRK3, DYRK4A and DYRK4B) Homo sapiens
physiological function role of DYRK2 in human cancer and as a potential oncogene. Overexpression of DYRK2 predicts a better survival in human non-small cell lung cancer, low expression level of DYRK2 correlates with poor prognosis in colorectal cancer. DYRK2 expression is significantly downregulated in colorectal cancer tissues compared with adjacent non-tumorous tissues. Enzyme DYRK2 inhibits cell invasion and migration in both HCT-116 and SW-480 cells and functions as a tumor suppressor in colorectal cancer cells. DYRK2 behaves as a proapoptotic kinase through phosphorylation of p53 at S46 which promotes its apoptotic activity. Downregulation of DYRK2 also induces a G2/M arrest. DYRK2 inhibits the proliferation, cell migration and invasion of colorectal cancer cells in vitro Homo sapiens