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Literature summary for 2.7.12.1 extracted from

  • Sitz, J.H.; Baumgaertel, K.; Haemmerle, B.; Papadopoulos, C.; Hekerman, P.; Tejedor, F.J.; Becker, W.; Lutz, B.
    The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4 (2008), Neuroscience, 157, 596-605.
    View publication on PubMed
Search for more literature for 2.7.12.1

Cloned(Commentary)

Cloned (Comment) Organism
EGFP-tagged DYRK1A is expressed in HEK-293 cell Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
harmine specific inhibitor of DYRK1A Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + neurodegeneration-related septin 4 Mus musculus SEPT4, also known as Pnutl2/CDCrel-2 ADP + phosphorylated neurodegeneration-related septin 4
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q61214
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
neocortex
-
 Mus musculus
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + neurodegeneration-related septin 4 SEPT4, also known as Pnutl2/CDCrel-2 Mus musculus ADP + phosphorylated neurodegeneration-related septin 4
-
 ?

Synonyms

Synonyms Comment Organism
dual-specificity tyrosine phosphorylation-regulated kinase 1A
-
 Mus musculus
DYRK1A
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus