Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + amphiphysin I | Mus musculus | - |
ADP + phosphorylated amphiphysin I | - |
? | |
ATP + caspase-9 | Mus musculus | - |
ADP + phosphorylated caspase-9 | - |
? | |
ATP + CREB | Mus musculus | - |
ADP + phosphorylated CREB | - |
? | |
ATP + cyclin L2 | Mus musculus | - |
ADP + phosphorylated cyclin L2 | - |
? | |
ATP + dynamin I | Mus musculus | - |
ADP + phosphorylated dynamin I | - |
? | |
ATP + eIF2Bepsilon | Mus musculus | - |
ADP + phosphorylated eIF2Bepsilon | - |
? | |
ATP + Gli1 protein | Mus musculus | - |
ADP + phosphorylated Gli1 protein | - |
? | |
ATP + glycogen synthase | Mus musculus | - |
ADP + phosphorylated glycogen synthase | - |
? | |
ATP + NFAT | Mus musculus | - |
ADP + phosphorylated NFAT | - |
? | |
ATP + Notch protein | Mus musculus | - |
ADP + phosphorylated Notch protein | - |
? | |
ATP + splicing factor 2 | Mus musculus | - |
ADP + phosphorylated splicing factor 2 | - |
? | |
ATP + splicing factor 3 | Mus musculus | - |
ADP + phosphorylated splicing factor 3 | - |
? | |
ATP + STAT3 | Mus musculus | - |
ADP + phosphorylated STAT3 | - |
? | |
ATP + synaptojanin I | Mus musculus | - |
ADP + phosphorylated synaptojanin I | - |
? | |
ATP + transcription factor FKHR | Mus musculus | - |
ADP + phosphorylated transcription factor FKHR | - |
? | |
additional information | Mus musculus | Dyrk1A undergoes self-activation through autophosphorylation at Tyr 321 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
cerebellum | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
olfactory bulb | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + amphiphysin I | - |
Mus musculus | ADP + phosphorylated amphiphysin I | - |
? | |
ATP + caspase-9 | - |
Mus musculus | ADP + phosphorylated caspase-9 | - |
? | |
ATP + CREB | - |
Mus musculus | ADP + phosphorylated CREB | - |
? | |
ATP + cyclin L2 | - |
Mus musculus | ADP + phosphorylated cyclin L2 | - |
? | |
ATP + dynamin I | - |
Mus musculus | ADP + phosphorylated dynamin I | - |
? | |
ATP + eIF2Bepsilon | - |
Mus musculus | ADP + phosphorylated eIF2Bepsilon | - |
? | |
ATP + Gli1 protein | - |
Mus musculus | ADP + phosphorylated Gli1 protein | - |
? | |
ATP + glycogen synthase | - |
Mus musculus | ADP + phosphorylated glycogen synthase | - |
? | |
ATP + NFAT | - |
Mus musculus | ADP + phosphorylated NFAT | - |
? | |
ATP + Notch protein | - |
Mus musculus | ADP + phosphorylated Notch protein | - |
? | |
ATP + splicing factor 2 | - |
Mus musculus | ADP + phosphorylated splicing factor 2 | - |
? | |
ATP + splicing factor 3 | - |
Mus musculus | ADP + phosphorylated splicing factor 3 | - |
? | |
ATP + STAT3 | - |
Mus musculus | ADP + phosphorylated STAT3 | - |
? | |
ATP + synaptojanin I | - |
Mus musculus | ADP + phosphorylated synaptojanin I | - |
? | |
ATP + transcription factor FKHR | - |
Mus musculus | ADP + phosphorylated transcription factor FKHR | - |
? | |
additional information | Dyrk1A undergoes self-activation through autophosphorylation at Tyr 321 | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dual-specificity tyrosine-phosphorylation regulated kinase 1A | - |
Mus musculus |
DYRK1A | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | Dyrk1A expression can be reressed by the AP4- geminin complex | down |
Mus musculus | Dyrk1A expression can be enhanced by treatment with beta-amyloid or overexpression of the transcription factor E2F1, Dyrk1A activity can be increased by binding of 14-3-3 protein | up |
General Information | Comment | Organism |
---|---|---|
malfunction | Dyrk1A participates in the pathogenic mechanisms underlying the mental and other physical symptoms of Down syndrome, alterations in Dyrk1A expression are frequently associated with Down syndrome phenotypes. Knock-out mice are embryonic lethal and heterozygous Dyrk1A mice exhibit decreased neonatal viability, developmental delay, and altered neocortical pyramidal cells | Mus musculus |