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Literature summary for 2.7.12.1 extracted from

  • Park, J.; Song, W.J.; Chung, K.C.
    Function and regulation of Dyrk1A: towards understanding Down syndrome (2009), Cell. Mol. Life Sci., 66, 3235-3240.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + amphiphysin I Mus musculus
-
ADP + phosphorylated amphiphysin I
-
?
ATP + caspase-9 Mus musculus
-
ADP + phosphorylated caspase-9
-
?
ATP + CREB Mus musculus
-
ADP + phosphorylated CREB
-
?
ATP + cyclin L2 Mus musculus
-
ADP + phosphorylated cyclin L2
-
?
ATP + dynamin I Mus musculus
-
ADP + phosphorylated dynamin I
-
?
ATP + eIF2Bepsilon Mus musculus
-
ADP + phosphorylated eIF2Bepsilon
-
?
ATP + Gli1 protein Mus musculus
-
ADP + phosphorylated Gli1 protein
-
?
ATP + glycogen synthase Mus musculus
-
ADP + phosphorylated glycogen synthase
-
?
ATP + NFAT Mus musculus
-
ADP + phosphorylated NFAT
-
?
ATP + Notch protein Mus musculus
-
ADP + phosphorylated Notch protein
-
?
ATP + splicing factor 2 Mus musculus
-
ADP + phosphorylated splicing factor 2
-
?
ATP + splicing factor 3 Mus musculus
-
ADP + phosphorylated splicing factor 3
-
?
ATP + STAT3 Mus musculus
-
ADP + phosphorylated STAT3
-
?
ATP + synaptojanin I Mus musculus
-
ADP + phosphorylated synaptojanin I
-
?
ATP + transcription factor FKHR Mus musculus
-
ADP + phosphorylated transcription factor FKHR
-
?
additional information Mus musculus Dyrk1A undergoes self-activation through autophosphorylation at Tyr 321 ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
cerebellum
-
Mus musculus
-
hippocampus
-
Mus musculus
-
olfactory bulb
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + amphiphysin I
-
Mus musculus ADP + phosphorylated amphiphysin I
-
?
ATP + caspase-9
-
Mus musculus ADP + phosphorylated caspase-9
-
?
ATP + CREB
-
Mus musculus ADP + phosphorylated CREB
-
?
ATP + cyclin L2
-
Mus musculus ADP + phosphorylated cyclin L2
-
?
ATP + dynamin I
-
Mus musculus ADP + phosphorylated dynamin I
-
?
ATP + eIF2Bepsilon
-
Mus musculus ADP + phosphorylated eIF2Bepsilon
-
?
ATP + Gli1 protein
-
Mus musculus ADP + phosphorylated Gli1 protein
-
?
ATP + glycogen synthase
-
Mus musculus ADP + phosphorylated glycogen synthase
-
?
ATP + NFAT
-
Mus musculus ADP + phosphorylated NFAT
-
?
ATP + Notch protein
-
Mus musculus ADP + phosphorylated Notch protein
-
?
ATP + splicing factor 2
-
Mus musculus ADP + phosphorylated splicing factor 2
-
?
ATP + splicing factor 3
-
Mus musculus ADP + phosphorylated splicing factor 3
-
?
ATP + STAT3
-
Mus musculus ADP + phosphorylated STAT3
-
?
ATP + synaptojanin I
-
Mus musculus ADP + phosphorylated synaptojanin I
-
?
ATP + transcription factor FKHR
-
Mus musculus ADP + phosphorylated transcription factor FKHR
-
?
additional information Dyrk1A undergoes self-activation through autophosphorylation at Tyr 321 Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
dual-specificity tyrosine-phosphorylation regulated kinase 1A
-
Mus musculus
DYRK1A
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus Dyrk1A expression can be reressed by the AP4- geminin complex down
Mus musculus Dyrk1A expression can be enhanced by treatment with beta-amyloid or overexpression of the transcription factor E2F1, Dyrk1A activity can be increased by binding of 14-3-3 protein up

General Information

General Information Comment Organism
malfunction Dyrk1A participates in the pathogenic mechanisms underlying the mental and other physical symptoms of Down syndrome, alterations in Dyrk1A expression are frequently associated with Down syndrome phenotypes. Knock-out mice are embryonic lethal and heterozygous Dyrk1A mice exhibit decreased neonatal viability, developmental delay, and altered neocortical pyramidal cells Mus musculus