Literature summary for 2.7.12.1 extracted from

Wegiel, J.; Dowjat, K.; Kaczmarski, W.; Kuchna, I.; Nowicki, K.; Frackowiak, J.; Mazur Kolecka, B.; Wegiel, J.; Silverman, W.P.; Reisberg, B.; Deleon, M.; Wisniewski, T.; Gong, C.X.; Liu, F.; Adayev, T.; Chen-Hwang, M.C.; Hwang, Y.W.
The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome (2008), Acta Neuropathol., 116, 391-407.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + tau protein-L-Thr434	Homo sapiens	-	ADP + [tau protein]-L-Thr434 phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + tau protein-L-Thr434	-	Homo sapiens	ADP + [tau protein]-L-Thr434 phosphate	-	?

Synonyms

Synonyms	Comment	Organism
DYRK1A	-	Homo sapiens
minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	there are higher levels of full-length DYRK1A in the brains of patients with Down syndrome when compared to control brains	up

General Information

General Information	Comment	Organism
malfunction	overexpressed DYRK1A contributes to neurofibrillary degeneration in Down syndrome more significantly than in subjects with two copies of the DYRK1A gene and sporadic Alzheimers disease	Homo sapiens

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Release 2023.1 (January 2023)