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Literature summary for 2.7.12.1 extracted from
- Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin (2009), Trends Pharmacol. Sci., 30, 129-137.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| H2O2 | the kinase activity of biliverdin reductase is stimulated by generators of free radicals such as H2O2 | Homo sapiens |  |
| sodium arsenite | the kinase activity of biliverdin reductase is stimulated by generators of free radicals such as sodium arsenite | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| biliverdin + ? | Homo sapiens | - |
bilirubin + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| biliverdin + ? | - |
Homo sapiens | bilirubin + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| biliverdin reductase | human biliverdin reductase is a dual-specificity kinase (Ser/Thr and Tyr) | Homo sapiens |
| BVR | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | human biliverdin reductase is an upstream activator of the insulin/insulin growth factor-1 and mitogen-activated protein kinase signaling pathways, and also a basic-leucine-zipper DNA/chromatin-binding transcription factor, an activator and anchor protein for translocation of protein kinase C betaII and zeta isozymes within cell compartments, and a kinase kinase for their activation. Biliverdin reductase is essential for mitogen-activated protein kinase-extracellular signal-regulated kinase 1/2-eukaryotic-like protein kinase signaling and has been identified as the cytoplasm-nuclear heme transporter of extracellular signal-regulated kinase 1/2 and hematin | Homo sapiens |
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