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Literature summary for 2.7.12.1 extracted from

  • Bogacheva, O.; Bogachev, O.; Menon, M.; Dev, A.; Houde, E.; Valoret, E.I.; Prosser, H.M.; Creasy, C.L.; Pickering, S.J.; Grau, E.; Rance, K.; Livi, G.P.; Karur, V.; Erickson-Miller, C.L.; Wojchowski, D.M.
    DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia (2008), J. Biol. Chem., 283, 36665-36675.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.12.1

Application

Application Comment Organism
medicine role of DYRK3 as an erythropoietic suppressor selectively during stress erythropoiesis, possible candidate for targeting by small molecule inhibitors as potentially important anti-anemia agents Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
genomic clones of DYRK3 isolated from a 129svJ Lambda phage library, transgenic mice generated, DYRK3 gene deletion in E14 ES cells using a floxed PGKneo targeting vector, targeted cells injected into C57BL/6J blastocysts, transgenic pA2gata1-DYRK3 mice prepared using an Myc epitope-tagged mDYRK3 cDNA within a pA2gata1 vector Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q922Y0 wild-type and transgenic mice, C57BL/6J strain, EpoR-HM mice
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Source Tissue

Source Tissue Comment Organism Textmining
erythroblast DYRK3 expression in, ex vivo analysis of erythroid progenitor cells of DYRK3-knockout mice Mus musculus
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testis DYRK3 expression in Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 increased reticulocyte production in DYRK3-knockout mice in response to hemolytic anemia due to DYRK3 deficiency, elevated reticulocyte and red cell formation in DYRK3-knockout mice after 5-fluorouracil-induced anemia, short term transplant experiments, DYRK3-knockout progenitors support enhanced erythroblast formation, erythropoietic advantages due to DYRK3-deficiency observed in 5-fluorouracil-treated mice expressing a compromised erythropoietin receptor EPOR-HM allele, transgenic pA2gata1-DYRK3 mice produce fewer reticulocytes during hemolytic anemia, pA2gata1-DYRK3 progenitors compromised in late pro-erythroblast formation ex vivo, DYRK3 inhibits transcriptional response pathways mediated by nuclear factor of activated T cells (NFAT) in erythroid K562 cells Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information DYRK3 attenuates red cell production selectively during anemia Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
DYRK3
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 Mus musculus