Activating Compound | Comment | Organism | Structure |
---|---|---|---|
TNF-alpha | stimulates the autophosphorylation of Goodpasture antigen-binding protein | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of FLAG-tagged Goodpasture antigen-binding protein in HEK-293A cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
human biliverdin reductase | i.e. hBVR, inhibits GPBP kinase activity, and hBVR decreases GPBP autophosphorylation in a concentration-dependent manner. A 7-residue peptide, KKRILHC281, corresponding to the core of the consensus D(delta)-Box motif in the interacting domain of hBVR, is as effective as the intact 296-residue hBVR polypeptide in inhibiting GPBP kinase activity. The D(delta)-Box motif is a common feature of kinases in the MAPK signaling cascade | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [Goodpasture antigen-binding protein] | Homo sapiens | the Goodpasture antigen-binding protein performs autophosphorylation | ADP + [Goodpasture antigen-binding phosphoprotein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Goodpasture antigen-binding protein performs autophosphorylation | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [Goodpasture antigen-binding protein] | the Goodpasture antigen-binding protein performs autophosphorylation | Homo sapiens | ADP + [Goodpasture antigen-binding phosphoprotein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Goodpasture antigen-binding protein kinase | - |
Homo sapiens |
GPBP kinase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | TNF-alpha-mediated transcriptional activation of GPBP, not affected by human biliverdin reductase | up |
General Information | Comment | Organism |
---|---|---|
metabolism | downregulation of GPBP kinase activity by human biliverdin reductase, protein-protein interactions between the two kinases, and regulation of the TNF-alpha/NFkappaB-dependent expression of GPBP by human biliverdin reductase | Homo sapiens |