Cloned (Comment) | Organism |
---|---|
gene COL4A3BP, DNA and amino acid sequence determinatio and analysis, gene COL4A3BP bears an alternative canonical translation initiation site, iMet, that extends the open reading frame of the 91-kDa polypeptide upstream by 45 residues, expression of FLAG-tagged GPBP in HeLa cells, two splicing variants GPBP and GPBPDELTA26/CERT. Native GPBP polypeptides of 91 kDa and 120 kDa are expressed insolubly associated with cellular membranes, whereas native GPBPDELTA26/CERT polypeptide of 77 kDa is expressed soluble in the cytoplasm, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isozyme GPBPDELTA26/CERT | Homo sapiens | 5829 | - |
endoplasmic reticulum | 91 kDa GPBP | Homo sapiens | 5783 | - |
extracellular | 77 kDa GPBP | Homo sapiens | - |
- |
Golgi apparatus | 91 kDa GPBP | Homo sapiens | 5794 | - |
membrane | 91 kDa GPBP | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + membrane type IV collagen | Homo sapiens | GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. The 91-kDa GPBP splicing variants regulates the levels of 77-kDa GPBP variant, i.e. GPBPDELTA26/CERT, in the extracellular compartment | ADP + phopshorylated membrane type IV collagen | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y5P4 | gene COL4A3BP | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + membrane type IV collagen | GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. The 91-kDa GPBP splicing variants regulates the levels of 77-kDa GPBP variant, i.e. GPBPDELTA26/CERT, in the extracellular compartment | Homo sapiens | ADP + phopshorylated membrane type IV collagen | - |
? | |
ATP + membrane type IV collagen | Goodpasture-antigen binding protein, GPBP, is a nonconventional Ser/Thr kinase for basement membrane type IV collagen. The 77-kDa GPBP is a soluble extracellular protein that interacts with type IV collagen | Homo sapiens | ADP + phopshorylated membrane type IV collagen | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GPBP | - |
Homo sapiens |
GPBPDELTA26/CERT | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |