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Literature summary for 2.7.11.8 extracted from

  • Jourdain, A.A.; Koppen, M.; Rodley, C.D.; Maundrell, K.; Gueguen, N.; Reynier, P.; Guaras, A.M.; Enriquez, J.A.; Anderson, P.; Simarro, M.; Martinou, J.C.
    A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function (2015), Cell Rep., 10, 1110-1121.
    View publication on PubMed
Search for more literature for 2.7.11.8

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
mitochondrion localizes to mitochondrial RNA granules Mus musculus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
-
 Mus musculus
60000
-
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [Fas-activated serine/threonine protein] Mus musculus
-
 ADP + [Fas-activated serine/threonine phosphoprotein]
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus Q9JIX9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
143B cell
-
 Mus musculus
-
MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [Fas-activated serine/threonine protein]
-
 Mus musculus ADP + [Fas-activated serine/threonine phosphoprotein]
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, mitochondrial isoform, SDS-PAGE Mus musculus
? x * 60000, cytosolic isoform, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
FASTK
-
 Mus musculus

General Information

General Information Comment Organism
malfunction ablating enzyme expression in cultured cells and mice results specifically in loss of ND6 mRNA and reduced complex I activity in vivo Mus musculus
physiological function the mitochondrial isoform is essential for ND6 mRNA biogenesis and complex I activity Mus musculus