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Literature summary for 2.7.11.7 extracted from
- Purification and identification of myosin heavy chain kinase from bovine brain (1984), J. Biochem., 95, 651-660.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no activation by cGMP | Bos taurus | |
| additional information | no activation by calmodulin, cAMP | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+/calmodulin | no inhibition | Bos taurus | |
| heparin | - |
Bos taurus |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | not required | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 160000 | - |
gel filtration | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin heavy chain | Bos taurus | - |
ADP + myosin heavy chain phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| enzyme copurifies with casein kinase II and Ca2+-independent myosin kinase | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + casein | - |
Bos taurus | ADP + casein phosphate | - |
? | |
| ATP + chicken gizzard myosin light chain | poor substrate | Bos taurus | ADP + chicken gizzard myosin light chain phosphate | - |
? | |
| ATP + histone 2A | no activity | Bos taurus | ADP + histone 2A phosphate | - |
? | |
| ATP + myosin heavy chain | - |
Bos taurus | ADP + myosin heavy chain phosphate | - |
? | |
| ATP + myosin heavy chain | protamine is no substrate | Bos taurus | ADP + myosin heavy chain phosphate | - |
? | |
| ATP + myosin heavy chain | no activity with myosins from gizzard, cardiac or skeletal muscle, but active with the isolated 20 kDa gizzard myosin light chain | Bos taurus | ADP + myosin heavy chain phosphate | - |
? | |
| ATP + myosin heavy chain | substrate: bovine brain myosin | Bos taurus | ADP + myosin heavy chain phosphate | - |
? | |
| ATP + myosin heavy chain | specific for myosin heavy chains, no phosphorylation of light chains | Bos taurus | ADP + myosin heavy chain phosphate | - |
? | |
| ATP + phosvitin | - |
Bos taurus | ADP + phosvitin phosphate | - |
? | |
| ATP + troponin T | - |
Bos taurus | ADP + troponin T phosphate | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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