Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + mitogen-activated protein kinase kinase | Homo sapiens | the enzyme promotes cell transformation or colorectal cancer by enhancing the MAPK signaling pathway through direct MEK phosphorylation | ADP + phosphorylated mitogen-activated protein kinase kinase | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O13874 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell line | the enzyme (BCKDK) is widely expressed in colorectal cancer patients, and patients that express higher levels of BCKDK have shorter survival times than those with lower levels | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + mitogen-activated protein kinase kinase | the enzyme promotes cell transformation or colorectal cancer by enhancing the MAPK signaling pathway through direct MEK phosphorylation | Homo sapiens | ADP + phosphorylated mitogen-activated protein kinase kinase | - |
? | |
ATP + mitogen-activated protein kinase kinase | phosphorylation of mitogen-activated protein kinase kinase (MEK) at Ser221 | Homo sapiens | ADP + phosphorylated mitogen-activated protein kinase kinase | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BCKDK | - |
Homo sapiens |
branched-chain alpha-keto acid dehydrogenase kinase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | rate-limiting enzyme in branched-chain amino acids catabolism | Homo sapiens |
physiological function | rate-limiting enzyme in branched-chain amino acids catabolism, which plays an important role in many serious human diseases. The enzyme promotes cell transformation or colorectal cancer by enhancing the MAPK signaling pathway through direct mitogen-activated protein kinase kinase (MEK) phosphorylation, rather than by branched-chain amino acids catabolism | Homo sapiens |