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Literature summary for 2.7.11.4 extracted from

  • Knapik-Czajka, M.
    Stimulation of rat liver branched-chain alpha-keto acid dehydrogenase activity by low doses of bezafibrate (2013), Toxicology, 306, 101-107.
    View publication on PubMed
Search for more literature for 2.7.11.4

Cloned(Commentary)

Cloned (Comment) Organism
BDK semi-quantitative real-time PCR expression analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] Rattus norvegicus inactivation by phosphorylation of BCKDH ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] inactivation by phosphorylation of BCKDH Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
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 ?

Synonyms

Synonyms Comment Organism
branched-chain alpha-keto acid dehydrogenase kinase
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 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus enzyme expression is reduced by 5% by bezafibrate down

General Information

General Information Comment Organism
metabolism the enzyme is involved in the regulation of the branched-chain alpha-keto acid dehydrogenase complex by inactivating it through phopshorylation, complex regulation and effects of the drug benzofibrate, overview Rattus norvegicus