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Literature summary for 2.7.11.4 extracted from

  • Kuzuya, T.; Katano, Y.; Nakano, I.; Hirooka, Y.; Itoh, A.; Ishigami, M.; Hayashi, K.; Honda, T.; Goto, H.; Fujita, Y.; Shikano, R.; Muramatsu, Y.; Bajotto, G.; Tamura, T.; Tamura, N.; Shimomura, Y.
    Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus (2008), Biochem. Biophys. Res. Commun., 373, 94-98.
    View publication on PubMed
Search for more literature for 2.7.11.4

Activating Compound

Activating Compound Comment Organism Structure
additional information dietary supplementation of branched-chain amino acid over several weeks increases the enzyme activity in spontaneous type II diabetic rats, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus The branched-chain alpha-keto acid dehydrogenase complex is the most important regulatory enzyme in branched-chain amino acid catabolism, regulation of hepatic BCKDH complex activity in spontaneous type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats and Zucker diabetic fatty rats, both showing reduced enzyme activity, overview ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
liver type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats and Zucker diabetic fatty rats Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information The branched-chain alpha-keto acid dehydrogenase complex is the most important regulatory enzyme in branched-chain amino acid catabolism, regulation of hepatic BCKDH complex activity in spontaneous type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats and Zucker diabetic fatty rats, both showing reduced enzyme activity, overview Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
BCKDH
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 Rattus norvegicus
branched-chain alpha-keto acid dehydrogenase
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 Rattus norvegicus