Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin-6 | directly activates AMPK in vivo and in vitro. Activates AMPK in skeletal muscle by increasing the concentration of cAMP and the AMP:ATP ratio. AMPK activation coincides temporally with a nearly 3fold increase in the AMP:ATP ratio in the extensor digitorum longus | Rattus norvegicus | |
isoproterenol | - |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'5'-dideoxyadenosine | inhibits ability of interleukin-6 to activate AMPK | Rattus norvegicus | |
propranolol | effects of interleukin-6 on both AMPK activity and energy state are inhibited by coincubation with propranolol, suggesting involvement of beta-adrenergic signaling | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
extensor digitorum longus | - |
Rattus norvegicus | - |
gastrocnemius | - |
Rattus norvegicus | - |
myotube | - |
Rattus norvegicus | - |
skeletal muscle | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
AMP-activated protein kinase | - |
Rattus norvegicus |
AMPK | - |
Rattus norvegicus |