Literature summary for 2.7.11.3 extracted from

Hamilton, S.R.; O'Donnell, J.B., Jr.; Hammet, A.; Stapleton, D.; Habinowski, S.A.; Means, A.R.; Kemp, B.E.; Witters, L.A.
AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit (2002), Biochem. Biophys. Res. Commun., 293, 892-898.

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Cloned(Commentary)

Cloned (Comment)	Organism
bacterially expressed recombinant alpha1 subunit proteins	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
T172D	site-directed mutagenesis	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]	Rattus norvegicus	important for the responses of cells to metabolic stresses such as lack of cell nutrients, hypoxia, ischemia and muscular exercise	ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]	-	Rattus norvegicus	ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]	-	?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]	important for the responses of cells to metabolic stresses such as lack of cell nutrients, hypoxia, ischemia and muscular exercise	Rattus norvegicus	ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]	-	?

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Release 2023.1 (January 2023)