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Literature summary for 2.7.11.3 extracted from

  • Hawley, S.A.; Selbert, M.A.; Goldstein, E.G.; Edelman, A.M.; Carling, D.; Hardie, D.G.
    5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms (1995), J. Biol. Chem., 270, 27186-27191.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Rattus norvegicus bicyclic phosphorylation system, enzyme is believed to be involved in protecting cells against ATP depletion due to environmental stress by inactivating several key biosynthetic enzymes ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] Rattus norvegicus phosphorylation activates EC 2.7.1.109 ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] bicyclic phosphorylation system, enzyme is believed to be involved in protecting cells against ATP depletion due to environmental stress by inactivating several key biosynthetic enzymes Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?
ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] phosphorylation activates EC 2.7.1.109 Rattus norvegicus ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]
-
 ?