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Literature summary for 2.7.11.27 extracted from

  • Kim, D.; Lee, J.E.; Jung, Y.J.; Lee, A.S.; Lee, S.; Park, S.K.; Kim, S.H.; Park, B.H.; Kim, W.; Kang, K.P.
    Metformin decreases high-fat diet-induced renal injury by regulating the expression of adipokines and the renal AMP-activated protein kinase/acetyl-CoA carboxylase pathway in mice (2013), Int. J. Mol. Med., 32, 1293-1302.
    View publication on PubMed
Search for more literature for 2.7.11.27

Activating Compound

Activating Compound Comment Organism Structure
metformin an AMPK activator Mus musculus

Application

Application Comment Organism
medicine clinical application of the enzyme activator metformin to obese or early diabetic patients may be helpful in preventing obesity- or diabetes-related kidney disease Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [acetyl-CoA carboxylase] Mus musculus
-
 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [acetyl-CoA carboxylase] Mus musculus C57BL/6
-
 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [acetyl-CoA carboxylase]
-
 Mus musculus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [acetyl-CoA carboxylase]
-
 Mus musculus C57BL/6 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Mus musculus
AMPK
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
metabolism AMPK activation by metformin regulates acetyl-CoA carboxylase (ACC) activity by its phosphoryla­tion. ACC is a rate-controlling enzyme for the synthesis of malonyl-CoA, which plays a critical role in the synthesis of fatty acids and the inhibition of mitochondrial fatty acid oxida­tion in the liver. the enzyme activator metformin decreases high-fat diet-induced renal injury by regulating the expression of adipokines and the renal AMP-activated protein kinase/acetyl-CoA carboxylase pathway in mice Mus musculus
physiological function AMPK activation by metformin regulates acetyl-CoA carboxylase (ACC) activity by its phosphoryla­tion. AMP-activated protein kinase (AMPK) is involved in the cellular metabolic response to metabolic stress. Metabolic stress, such as impaired ATP production or accelerated ATP consumption activate the AMP-activated protein kinase (AMPK) system, which acts as a sensor of cellular energy metabolism Mus musculus