Literature summary for 2.7.11.27 extracted from

Janovska, A.; Hatzinikolas, G.; Staikopoulos, V.; McInerney, J.; Mano, M.; Wittert, G.A.
AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity (2008), Mol. Cell. Endocrinol., 284, 1-10.

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Activating Compound

Activating Compound	Comment	Organism	Structure
cAMP	-	Rattus norvegicus
leptin	stimulates fatty acid oxidation via the phosphorylation of AMPK and acetyl-CoA carboxylase, the stimulation by leptin is muscle fibre type-dependent and fails in diet-induced obesity	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [acetyl-CoA carboxylase]	Rattus norvegicus	-	ADP + [acetyl-CoA carboxylase] phosphate	-	?
additional information	Rattus norvegicus	leptin stimulates fatty acid oxidation via the phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase. Obesity is associated with resistance to the effects of leptin, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	lean and obese Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skeletal muscle	stimulation of AMPKalpha by leptin differs in tissue of lean and obese rats, overview	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [acetyl-CoA carboxylase]	-	Rattus norvegicus	ADP + [acetyl-CoA carboxylase] phosphate	-	?
additional information	leptin stimulates fatty acid oxidation via the phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase. Obesity is associated with resistance to the effects of leptin, overview	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
AMPK	-	Rattus norvegicus
AMPKalpha	-	Rattus norvegicus
cAMP-activated protein kinase	-	Rattus norvegicus

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Release 2023.1 (January 2023)