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Literature summary for 2.7.11.27 extracted from

  • Cesquini, M.; Stoppa, G.R.; Prada, P.O.; Torsoni, A.S.; Romanatto, T.; Souza, A.; Saad, M.J.; Velloso, L.A.; Torsoni, M.A.
    Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats (2008), Life Sci., 82, 1262-1271.
    View publication on PubMed
Search for more literature for 2.7.11.27

Activating Compound

Activating Compound Comment Organism Structure
cAMP
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ARA-A a competitive inhibitor of AMPK Rattus norvegicus
citrate strong inhibitor of the hypothalamic and the hepatic enzyme after intracerebroventricular injection and during fasting, rats treated with citrate present improved insulin signal transduction in liver, skeletal muscle, and epididymal fat pad, overview, no influence on enzyme expression Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [acetyl-CoA carboxylase] Rattus norvegicus the hypothalamic AMP-activated protein kinase/acetyl-CoA carboxylase, i.e. AMPK/ACC, pathway plays an important role in the control of food intake and energy expenditure, overview ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
additional information Rattus norvegicus the enzyme activity in liver is associated to insulin signal transduction, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar Hannover rats
-

Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [acetyl-CoA carboxylase]
-
 Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
ATP + [acetyl-CoA carboxylase] the hypothalamic AMP-activated protein kinase/acetyl-CoA carboxylase, i.e. AMPK/ACC, pathway plays an important role in the control of food intake and energy expenditure, overview Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
additional information the enzyme activity in liver is associated to insulin signal transduction, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
AMPK
-
 Rattus norvegicus
cAMP-activated protein kinase
-
 Rattus norvegicus