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Literature summary for 2.7.11.26 extracted from

  • Petit-Paitel, A.; Brau, F.; Cazareth, J.; Chabry, J.
    Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neurons (2009), PLoS ONE, 4, e5491.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.26

Inhibitors

Inhibitors Comment Organism Structure
kenpaullone
-
 Mus musculus
LiCl
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol 1-methyl-4-phenylpyridinium iodide treatment induces a significant decrease of the specific phospho-Tyr216-GSK-3beta labeling in mitochondria concomitantly with an increase into the cytosol Mus musculus 5829
-
mitochondrion GSK-3beta partially localizes within mitochondria Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein GSK-3beta is activated by phosphorylation of the tyrosine 216 residue located in the kinase domain and inactivated by phosphorylation of the amino-terminal serine 9 residue Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Mus musculus
-
TSM1 cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3beta
-
 Mus musculus
GSK-3beta
-
 Mus musculus

General Information

General Information Comment Organism
physiological function GSK-3beta is a critical mediator of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/1-methyl-4-phenylpyridinium iodide-induced neurotoxicity through its ability to regulate mitochondrial functions Mus musculus