Literature summary for 2.7.11.26 extracted from

Hong, X.P.; Peng, C.X.; Wei, W.; Tian, Q.; Liu, Y.H.; Yao, X.Q.; Zhang, Y.; Cao, F.Y.; Wang, Q.; Wang, J.Z.
Essential role of tau phosphorylation in adult hippocampal neurogenesis (2010), Hippocampus, 20, 1339-1349.

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Inhibitors

Inhibitors	Comment	Organism	Structure
SB216763	specific GSK-3 inhibitor	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	the serine-9 phosphorylated GSK-3beta form is inactive	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
hippocampus	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + protein tau	-	Rattus norvegicus	ADP + protein tau phosphate	-	?

Synonyms

Synonyms	Comment	Organism
glycogen synthase kinase-3beta	-	Rattus norvegicus
GSK-3beta	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	protein tau phosphorylation plays an essential role in adult hippocampal neurogenesis and GSK-3 facilitates neurogenesis only in the presence of tau proteins, tau hyperphosphorylation induced by activating GSK-3 promotes neurogenesis	Rattus norvegicus

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Release 2023.1 (January 2023)