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Literature summary for 2.7.11.26 extracted from

  • Li, T.; Paudel, H.K.
    Glycogen synthase kinase 3beta phosphorylates Alzheimers disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism (2006), Biochemistry, 45, 3125-3133.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
Flag-tagged wild-type or various mutant tau and HA-tagged GSK3beta cotransfected in HEK-293 cells Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein tau Bos taurus phosphorylates tau on S202, T231, S396, and S400 but not on S262, S235, and S404. Phosphorylates tau directly at S202 but requires the previous phosphorylation on S235 to phosphorylate T231, once a priming kinase phosphorylates S404, GSK3beta sequentially phosphorylates S400 and then S396 ADP + protein tau phosphate
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Organism

Organism UniProt Comment Textmining
Bos taurus
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Source Tissue

Source Tissue Comment Organism Textmining
brain interaction of GSK3beta and tau Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau phosphorylates tau on S202, T231, S396, and S400 but not on S262, S235, and S404. Phosphorylates tau directly at S202 but requires the previous phosphorylation on S235 to phosphorylate T231, once a priming kinase phosphorylates S404, GSK3beta sequentially phosphorylates S400 and then S396 Bos taurus ADP + protein tau phosphate
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Synonyms

Synonyms Comment Organism
GSK-3beta
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Bos taurus