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Literature summary for 2.7.11.26 extracted from

  • Harris, F.M.; Brecht, W.J.; Xu, Q.; Mahley, R.W.; Huang, Y.
    Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc (2004), J. Biol. Chem., 279, 44795-44801.
    View publication on PubMed
Search for more literature for 2.7.11.26

Activating Compound

Activating Compound Comment Organism Structure
additional information tau phosphorylation in vivo is stimulated by extracellular signal-regulated kinase Erk phosphorylation and apolipoprotein E4, Erk phosphorylation is stinulated by Zn2+ and inhibited by MEK-inhibitor U0126 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [tau-protein] Mus musculus tau phosphorylation in vivo is stimulated by extracellular signal-regulated kinase Erk phosphorylation and apolipoprotein isozyme E4, to a lesser extent by isozyme apoE3, overview ADP + O-phospho-[tau-protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 apolipoprotein E4 transgenic mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-
Neuro-2a cell cell line stably expressing human apolipoprotein apoE4 Mus musculus
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [tau-protein]
-
 Mus musculus ADP + O-phospho-[tau-protein]
-
 ?
ATP + [tau-protein] tau phosphorylation in vivo is stimulated by extracellular signal-regulated kinase Erk phosphorylation and apolipoprotein isozyme E4, to a lesser extent by isozyme apoE3, overview Mus musculus ADP + O-phospho-[tau-protein]
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus