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Literature summary for 2.7.11.26 extracted from
- Stress-induced hyperphosphorylation of tau in the mouse brain (2003), FEBS Lett., 535, 183-189.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | starvation- and cold-water stress-induced reversible hyperphosphorylation of tau at S199, S202, T205, T231, and S235 in the brain | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [tau-protein] | Mus musculus | regulation, overview | ADP + O-phospho-[tau-protein] | - |
? |  |
| additional information | Mus musculus | rapid, reversible cold-water stress-induced hyperphosphorylation of tau S199, S202, T205, T231, and S235 in hippocampal and cerebral region of the brain, hyperphosphorylation of tau is associated to the Alzheimer's disease | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
male C57BL/6Njcl mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | hyperphosphorylation in hippocampal and cerebral regions, weak in the cerebellum | Mus musculus | - |
| cerebral cortex | cold-water stress-induced tau phosphorylation pattern | Mus musculus | - |
| hippocampus | tau phosphorylation pattern | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [tau-protein] | - |
Mus musculus | ADP + O-phospho-[tau-protein] | - |
? | |
| ATP + [tau-protein] | regulation, overview | Mus musculus | ADP + O-phospho-[tau-protein] | - |
? | |
| additional information | rapid, reversible cold-water stress-induced hyperphosphorylation of tau S199, S202, T205, T231, and S235 in hippocampal and cerebral region of the brain, hyperphosphorylation of tau is associated to the Alzheimer's disease | Mus musculus | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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