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Literature summary for 2.7.11.25 extracted from

  • Suarez-Rodriguez, M.C.; Adams-Phillips, L.; Liu, Y.; Wang, H.; Su, S.H.; Jester, P.J.; Zhang, S.; Bent, A.F.; Krysan, P.J.
    MEKK1 is required for flg22-induced MPK4 activation in Arabidopsis plants (2007), Plant Physiol., 143, 661-669.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
additional information may play a structural role in signaling, independent of its protein kinase activity, MEKK1 kinase activity may not be required to activate FLS2-mediated defense responses in Arabidopsis. MEKK1 acts upstream of MPK4 as a negative regulator of pathogen response pathways, a function that may not require MEKK1's full kinase activity Arabidopsis thaliana

Cloned(Commentary)

Cloned (Comment) Organism
MEKK1 and mutant K361M constructs introduced into Arabidopsis plants via Agrobacterium transformation Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
K361M kinase-inactive MEKK1, rescues the mekk1 dwarf penotype. Elevated temperature dramatically improves the growth of mekk1 plants. K361M plants are fully fertile and grow with a morphology closely resembling wild-type plants. When treated with pathogenic bacteria, K361M plants are slightly more susceptible to an avirulent strain of Pseudomonas syringae and show a delayed hypersensitive response Arabidopsis thaliana
additional information mekk1 knockout mutants, display a severe dwarf phenotype, constitutive callose deposition, and constitutive expression of pathogen response genes. The dwarf phenotype is largely rescued by introduction into mekk1 knockout plants of either mutant K361M or a nahG transgene that degrades salicylic acid Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
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Columbia ecotype
-

Storage Stability

Storage Stability Organism
-80°C Arabidopsis thaliana

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myelin basic protein
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Arabidopsis thaliana ADP + phosphorylated myelin basic protein
-
?
additional information activity of MEKK1 may not be required for flg22-induced MPK4, MPK3 or MPK6 activation or for other macroscopic FLS2-mediated responses Arabidopsis thaliana ?
-
?

Synonyms

Synonyms Comment Organism
MEKK1
-
Arabidopsis thaliana
mitogen-activated protein kinase kinase kinase
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Arabidopsis thaliana