Application | Comment | Organism |
---|---|---|
additional information | may play a structural role in signaling, independent of its protein kinase activity, MEKK1 kinase activity may not be required to activate FLS2-mediated defense responses in Arabidopsis. MEKK1 acts upstream of MPK4 as a negative regulator of pathogen response pathways, a function that may not require MEKK1's full kinase activity | Arabidopsis thaliana |
Cloned (Comment) | Organism |
---|---|
MEKK1 and mutant K361M constructs introduced into Arabidopsis plants via Agrobacterium transformation | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
K361M | kinase-inactive MEKK1, rescues the mekk1 dwarf penotype. Elevated temperature dramatically improves the growth of mekk1 plants. K361M plants are fully fertile and grow with a morphology closely resembling wild-type plants. When treated with pathogenic bacteria, K361M plants are slightly more susceptible to an avirulent strain of Pseudomonas syringae and show a delayed hypersensitive response | Arabidopsis thaliana |
additional information | mekk1 knockout mutants, display a severe dwarf phenotype, constitutive callose deposition, and constitutive expression of pathogen response genes. The dwarf phenotype is largely rescued by introduction into mekk1 knockout plants of either mutant K361M or a nahG transgene that degrades salicylic acid | Arabidopsis thaliana |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
Columbia ecotype | - |
Storage Stability | Organism |
---|---|
-80°C | Arabidopsis thaliana |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myelin basic protein | - |
Arabidopsis thaliana | ADP + phosphorylated myelin basic protein | - |
? | |
additional information | activity of MEKK1 may not be required for flg22-induced MPK4, MPK3 or MPK6 activation or for other macroscopic FLS2-mediated responses | Arabidopsis thaliana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MEKK1 | - |
Arabidopsis thaliana |
mitogen-activated protein kinase kinase kinase | - |
Arabidopsis thaliana |