Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation of the enzyme by MAPK kinase MEK activates the enzyme. U0126, a specific inhibitor of MEK (MAPK kinase), blocks the activation of MAPK3/1 and subsequently of EGF-mediated downstream MAPK3/1 pathway | Ovis aries |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation of the enzyme by MAPK kinase MEK activates the enzyme. U0126, a specific inhibitor of MEK (MAPK kinase), blocks the activation of MAPK3/1 and subsequently of EGF-mediated downstream MAPK3/1 pathway | Ovis aries |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | W5P0L9 | - |
- |
Ovis aries | W5Q1R8 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of the enzyme by MAPK kinase MEK activates the enzyme | Ovis aries |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | - |
Ovis aries | - |
Synonyms | Comment | Organism |
---|---|---|
ERK1 | - |
Ovis aries |
ERK2 | - |
Ovis aries |
MAPK1 | - |
Ovis aries |
MAPK3 | - |
Ovis aries |
mitogen-activated protein kinase 1 | - |
Ovis aries |
mitogen-activated protein kinase 3 | - |
Ovis aries |
General Information | Comment | Organism |
---|---|---|
physiological function | effect of EGF-mediated mitogen-activated protein kinases 3 and 1 (MAPK3/1) pathway on in vitro cytoplasmic maturation of sheep oocytes, overview. The key downstream effectors of EGFR signaling in cumulus cells, mitogen-activated protein kinases 3 and 1 (MAPK3/1, also known as ERK1/2), is essential for mammalian oocyte maturation. Maturation of mammalian oocytes is a complex and dynamic process involving the maturation of nucleus and cytoplasm | Ovis aries |