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Literature summary for 2.7.11.24 extracted from

  • Chai, B.; Li, J.Y.; Zhang, W.; Wang, H.; Mulholland, M.W.
    Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling (2009), Peptides, 30, 1098-1104.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
a plasmid encoding Flag-JNK1 is used Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
[Nle4, D-Phe7]alpha-melanocyte stimulating hormone NDP-MSH, the melanocortin agonist dose-dependently inhibits JNK activity in HEK-293 cells stably expressing the human melanocortin receptor type 4 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Homo sapiens
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell a plasmid encoding Flag-JNK1 is transformed into HEK-293 cells expressing the melanocortin receptor type 4 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Homo sapiens ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
c-Jun N-terminal kinase
-
 Homo sapiens
JNK
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens