Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glial cell line-derived neurotrophic factor | GDNF | Rattus norvegicus | |
neurotrophic growth factor | NGF | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene | U0126 | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
determined by SDS-PAGE and Western-blot analysis | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Rattus norvegicus | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague Dawley rat | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ganglion | dorsal root ganglion | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Rattus norvegicus | ADP + a phosphoprotein | - |
? | |
ATP + sodium channel Na(v)1.6 | - |
Rattus norvegicus | ADP + phosphorylated sodium channel Na(v)1.6 | - |
? | |
ATP + sodium channel Na(v)1.7 | - |
Rattus norvegicus | ADP + phosphorylated sodium channel Na(v)1.7 | - |
? | |
ATP + sodium channel Na(v)1.8 | - |
Rattus norvegicus | ADP + phosphorylated sodium channel Na(v)1.8 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ERK1/2 mitogen-activated protein kinase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
kinase assay | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | pERK1/2 appears to specifically modulate gating properties of Na(v)1.7, an effect that may contribute to the role of this channel in dorsal root ganglion neuron excitability | Rattus norvegicus |