Application | Comment | Organism |
---|---|---|
medicine | p38 mitogen-activated protein kinase is a promising target for the treatment of chronic inflammatory diseases such as rheumatoid arthritis | Mammalia |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[(2,4-difluorophenyl)amino]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one | - |
Mammalia | |
2-[(2,4-difluorophenyl)amino]-5H-dibenzo[a,d][7]annulen-5-one | - |
Mammalia | |
2-[(2-amino-4-fluorophenyl)amino]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one | - |
Mammalia | |
2-[(2-aminophenyl)amino]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one | - |
Mammalia | |
2-[(2-aminophenyl)amino]-5H-dibenzo[a,d][7]annulen-5-one | - |
Mammalia | |
3-[(2,4-difluorophenyl)amino]dibenzo[b,e]oxepin-11(6H)-one | - |
Mammalia | |
3-[(2-amino-4-fluorophenyl)amino]dibenzo[b,e]oxepin-11(6H)-one | - |
Mammalia | |
3-[(2-aminophenyl)amino]dibenzo[b,e]oxepin-11(6H)-one | - |
Mammalia | |
8-[(2,4-difluorophenyl)amino]-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one | - |
Mammalia | |
8-[(2,4-difluorophenyl)amino]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one | - |
Mammalia | |
8-[(2,4-difluorophenyl)amino][1]benzoxepino[3,4-b]pyridin-5(11H)-one | - |
Mammalia | |
8-[(2-amino-4-fluorophenyl)amino]-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one | - |
Mammalia | |
8-[(2-amino-4-fluorophenyl)amino][1]benzoxepino[3,4-b]pyridin-5(11H)-one | - |
Mammalia | |
8-[(2-aminophenyl)amino]-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one | - |
Mammalia | |
8-[(2-aminophenyl)amino]-11H-benzo[5,6]cyclohepta[1,2-c]pyridin-11-one | - |
Mammalia | |
8-[(2-aminophenyl)amino]-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one | - |
Mammalia | |
8-[(2-aminophenyl)amino]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one | - |
Mammalia | |
8-[(2-aminophenyl)amino][1]benzoxepino[3,4-b]pyridin-5(11H)-one | - |
Mammalia | |
SB203580 | - |
Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Mammalia | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Mammalia | ADP + a phosphoprotein | - |
? | |
ATP + ATF-2 | substrate in kinase activity assay | Mammalia | ADP + phosphorylated ATF-2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAP kinase | - |
Mammalia |
mitogen-activated kinase | - |
Mammalia |
p38 mitogen-activated protein kinase | - |
Mammalia |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mammalia |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00004 | - |
- |
Mammalia | 3-[(2-amino-4-fluorophenyl)amino]dibenzo[b,e]oxepin-11(6H)-one | |
0.00005 | - |
- |
Mammalia | SB203580 | |
0.0001 | - |
- |
Mammalia | 2-[(2-aminophenyl)amino]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one | |
0.00013 | - |
- |
Mammalia | 2-[(2,4-difluorophenyl)amino]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one | |
0.00013 | - |
- |
Mammalia | 2-[(2-amino-4-fluorophenyl)amino]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one | |
0.00018 | - |
- |
Mammalia | 8-[(2,4-difluorophenyl)amino][1]benzoxepino[3,4-b]pyridin-5(11H)-one | |
0.00024 | - |
- |
Mammalia | 3-[(2,4-difluorophenyl)amino]dibenzo[b,e]oxepin-11(6H)-one | |
0.00024 | - |
- |
Mammalia | 8-[(2,4-difluorophenyl)amino]-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one | |
0.0003 | - |
- |
Mammalia | 3-[(2-aminophenyl)amino]dibenzo[b,e]oxepin-11(6H)-one | |
0.00031 | - |
- |
Mammalia | 8-[(2-aminophenyl)amino]-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one | |
0.00033 | - |
- |
Mammalia | 8-[(2,4-difluorophenyl)amino]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one | |
0.00044 | - |
- |
Mammalia | 8-[(2-aminophenyl)amino]-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one | |
0.00106 | - |
- |
Mammalia | 2-[(2-aminophenyl)amino]-5H-dibenzo[a,d][7]annulen-5-one | |
0.00108 | - |
- |
Mammalia | 8-[(2-aminophenyl)amino]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one | |
0.00119 | - |
- |
Mammalia | 8-[(2-amino-4-fluorophenyl)amino]-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one | |
0.00195 | - |
- |
Mammalia | 8-[(2-aminophenyl)amino]-11H-benzo[5,6]cyclohepta[1,2-c]pyridin-11-one | |
0.00253 | - |
- |
Mammalia | 2-[(2,4-difluorophenyl)amino]-5H-dibenzo[a,d][7]annulen-5-one | |
0.00268 | - |
- |
Mammalia | 8-[(2-aminophenyl)amino][1]benzoxepino[3,4-b]pyridin-5(11H)-one | |
0.00273 | - |
- |
Mammalia | 8-[(2-amino-4-fluorophenyl)amino][1]benzoxepino[3,4-b]pyridin-5(11H)-one |