Literature summary for 2.7.11.24 extracted from

Bashor, C.J.; Helman, N.C.; Yan, S.; Lim, W.A.
Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics (2008), Science, 319, 1539-1543.

Search for more literature for 2.7.11.24

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	Fus3 is phosphorylated and activated by Ste7. Building synthetic feedback loops by dynamically regulating recruitment of modulators to the Ste5 scaffold, negative- and positive-feedback loop design, leads to activation of inhibition of the Fus3, overview	Saccharomyces cerevisiae

Application

Application	Comment	Organism
pharmacology	protein scaffolds, e.g. of MAP kinases, provide a flexible platform for reprogramming cellular responses and could be exploited to engineer cells with novel therapeutic and biotechnological functions	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
additional information	the Ste5 scaffold protein can be used as a platform to systematically reshape output of the yeast mating MAP kinase pathway, construction of synthetic positive- and negative-feedback loops by dynamically regulating recruitment of pathway modulators to an artificial binding site on Ste5, they show ultrasensitive dose response, accelerated or delayed response times, and tunable adaptation, overview	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	Msg5 is a MAPK phosphatase that deactivates Fus3 by dephosphorylation. Building synthetic feedback loops by dynamically regulating recruitment of modulators to the Ste5 scaffold, negative- and positive-feedback loop design, leads to activation of inhibition of the Fus3, overview	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P16892	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	Fus3 is phosphorylated and activated by Ste7, Msg5 is a MAPK phosphatase that deactivates Fus3 by dephosphorylation	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
Fus3	-	Saccharomyces cerevisiae
MAP kinase	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)