Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation activates MAPKs, PD98059 inhibits ERK1/2 phosphorylation by MEK1/2, i.e. mitogen-activated kinase-extracellular signal-regulated kinase kinase, p38 MAPK is activated in asthma patient airway cells, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27361 | Erk1 | - |
Homo sapiens | P28482 | ERK2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation activates MAPKs, PD98059 inhibits ERK1/2 phosphorylation by MEK1/2, i.e. mitogen-activated kinase-extracellular signal-regulated kinase kinase | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | from airway tissue | Homo sapiens | - |
additional information | distribution of phosphorylated active MAPKs in airway tissues of healthy persons and of paients with mild or severe asthma, phosphorylated p38 is increased in epithelium of asthmatic samples, overview | Homo sapiens | - |
respiratory tract | - |
Homo sapiens | - |
smooth muscle | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ERK1 | - |
Homo sapiens |
ERK2 | - |
Homo sapiens |
extracellular regulated kinase | - |
Homo sapiens |
MAPK | - |
Homo sapiens |
p38 MAPK | - |
Homo sapiens |